The overall goal of this project is to develop computational modeling frameworks that couple systemic circulation of the left ventricular and coronary perfusion with flow regulation mechanisms to investigate myocardial demand-supply 1) under graded exercise conditions; 2) in transmural locations across the heart wall; for health and patients with cardiovascular diseases. Research findings from this project can 1) overcome some limitations in pure experimental/clinical studies as demand is a virtual parameter that cannot be measured; 2) elucidate the effects of left ventricular geometry and mechanics on demand-supply mismatch transmurally; 3) understand the mechanisms of some clinical observations.
